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Lamivudine /Zidovudine Common Use
Combivir is a combination of lamivudine (Epivir) and zidovudine (Retrovir), both components are active against the human immunodeficiency virus (HIV) and inhibit the activity of reverse transcriptase blocking the production of DNA and new viruses. Separately zidovudine and lamivudine may not be so effective as their combination which makes it more difficult for HIV to produce high resistant strains.
Lamivudine /Zidovudine Dosage And Direction
Adults and children under 12 years of age should take Combivir once daily. Take the drug about the same time each day to avoid missing a dose. Food does not change absorption of the medication.
Lamivudine /Zidovudine Precautions
Combivir can affect the body's acid balance. It also can be a reason to low blood cell counts (anemia). Inform your doctor if you have an existing shortage of blood cells or a disease of the bone marrow before to start treatment with Combivir. Aggravation of chronic liver disease hepatitis B is possible when treatment with Combivir is finished as its virus causative agent becomes resistant to lamivudine. Combivir sometimes causes muscle pain and inflammation, especially inflammation of the pancreas (pancreatitis). If you have abdominal pain for several days, accompanied by nausea and vomiting yo should immediately check with your doctor. Drugs for HIV may cause a redistribution of body fat: (a "buffalo hump" on the back, extra fat around the middle, and wasting in the arms, legs, and face).
Lamivudine /Zidovudine Contraindications
Hypersensitivity to lamivudine or zidovudine. It cannot be used in people with low weigh (less than 110 pounds, or 50 kg). Children and patients with poor kidney or liver function who may require dose correction should not take tablets of Combivir as they contain fixed doses of amivudine or zidovudine.
Lamivudine /Zidovudine Possible Side Effect
Serious side effects of Combivir are: decrease in blood cells, muscle breakdown, muscle pain (myopathy), liver enlargement and metabolic disturbance (lactic acidosis), allergy symptoms (rash, chills), nausea and vomiting, abdominal pain, weight loss, headache, cough and insomnia.
Lamivudine /Zidovudine Interaction
Inform your doctor if you are takeing fluconazole (Diflucan), probenecid, trimethoprim (Trimpex) and valproic acid (Depakote). These drugs reduce the elimination of zidovudine and may lead to its increased blood concentration.
Lamivudine /Zidovudine Missed dose
Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.
Lamivudine /Zidovudine Overdose
Any medication taken in excessive quantities may be dangerous. Notify your doctor immediately in case of a supposed overdose and experience dizziness, drowsiness, confusion, headache, fatigue, weakness, nausea, seizure, vomiting.
Lamivudine /Zidovudine Storage
Combivir should be stored at room temperature between 2-30?C (36-86 F).
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